Pathogenic microbes are responsible for billions of dollars in economic losses worldwide each year. In order to discover new antimicrobial molecules with good activity against P. fumigatus, C. albicans, A. fumigates, E. fecalis, P. aeurogenosa, S. aureus, E. coli, S. mutans, K. pneumonia, A. niger. , we sought to combine the active substructure of aryl-pyrimidines and aromatic amine derivatives together to design and synthesize novel pyrazolo[2,4-d]pyrimidines. A series of novel pyrazolo [2,4-d] pyrimidines were synthesized by MWI (Microwave Irradiation). The synthesized compounds Ii-Ixii, IIi-IIiv, IIIi-IIIii, IVi, Vi were characterized by IR , Mass and NMR . The preliminary biological assays revealed that most of the synthesized compounds exhibit promising antimicrobial activities against A. fumigatus, C. albicans .
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